CTNNB1 and cancer: Most neoplastic diseases are not of familial origin, but the inheritance of cancer genes can increase the risk of specific types In general, some cancers are linked to mutations in genes inherited from parental lineage, such as BRCA1 and BRCA2, PTEN, WT1, WTX, CTNNB1, TP53, APC, and DICER1 (3, 5).