GLP1R and obesity due to melanocortin 4 receptor deficiency: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), the natural homologs of the incretin hormone GLP-1, have been approved for weight management (7); 2.4 milligrams (mg) of semaglutide once weekly or 3.0 mg of liraglutide once daily is effective in treating obesity (7).