In contrast to the observed increase in inflammatory helper T cell subsets in the periphery of the CD4-Cre PRR cKO mice (Figures 4D–G), the number of tumor-infiltrating CD4 and CD8 T cells was significantly lower, and the frequency of IFN-γ-producing cells was unchanged compared to that in control mice (Figures 6D, E). The gene discussed is CD8A; the disease is neoplasm.