Regarding the reprogramming of fatty acid synthesis, AML cells trigger the fatty acid synthesis pathway by upregulating important synthases like ACC (acetyl coenzyme A carboxylase) and FASN (fatty acid synthase), which catalyze the production of precursors like malonyl coenzyme A, creating a “metabolic double-edged sword” effect (103). This evidence concerns the gene FASN and acute myeloid leukemia.