Significantly higher PD-1 expression on the surface of CD8 T cells and raised CD161 expression on the surface of CD4 T cells are both observed in individuals with AML relapse; these alterations are associated with an increased risk of disease recurrence.Subsets of immunosuppressive cells are important in the extracellular route (147). This evidence concerns the gene KLRB1 and acute myeloid leukemia.