ENTPD1 and neoplasm: QD/POM1@NP@M encapsulates Ag2S quantum dots and the CD39 inhibitor POM1, with homologous tumor cell membrane coating enhancing targeting. SDT induces ICD to release ATP, triggering an immune response. POM1 inhibits CD39 to reduce adenosine accumulation, improve the immunosuppressive microenvironment, promote anti-tumor immune cell infiltration, and transform the tumor from “cold” to “hot.” Combining with α-PDL1 enhances systemic anti-tumor immunity and promotes long-term immune memory.