HMGB1 and neoplasm: Figure 1 illustrates the process of SDT-induced immunogenic cell death (ICD) in vivo, depicting how low-intensity ultrasound activates nanoparticle-delivered sonosensitizers to generate ROS, causing oxidative damage and DAMPs release (CRT, ATP, HMGB1) from tumor cells, which triggers DC maturation, T-cell activation, and TME reprogramming, ultimately converting cold tumors into hot tumors with enhanced antitumor immunity.