CD274 and glioblastoma: AMNP@J + C achieves co-delivery of Ce6 and JQ1, producing synergistic antitumor effects in vitro and in vivo and improving survival in GBM mice. SDT generates ROS to kill tumor cells and induce ICD, while JQ1 inhibits tumor proliferation and PD-L1 expression, enhancing the antitumor immune response.