CXCR2 and non-small cell lung carcinoma: In NSCLC, LTB4 recruits neutrophils through the leukotriene B4 receptor-1(BLT1) receptor, activating a ROS-dependent DNA damage pathway (193), whereas IL-8 promotes neutrophil infiltration via the CXCR1/CXCR2 axis, leading to MMP-9 release, ECM degradation, and angiogenesis (194).