In contrast, tumour-suppressive neutrophil subsets exhibit antitumour activity: N1-TANs induce tumour apoptosis through ADCC and TNF-related apoptosis-inducing ligand(TRAIL) signalling, whereas N5 is enriched in LUAD and defined by IFN response genes, implicating a specialised role in antitumour immunity (26, 141). This evidence concerns the gene TNFSF10 and neoplasm.