The HCC liver prevalent clusters represented respectively adaptive NK cells in cluster 19 (37.6% of total NK cells in HCC liver donor 2; CD56dimCD16+CD314+ CD159a-CD159c+CD158b, a_h-CD161-CD159a-CD57HiGranzymeB+Perforin-TIGIT+CD85j+), and mature NK cells in both cluster 18 (44.6% of total NK cells in HCC liver donor 2; CD56dimCD16+CD159c-CD158b, a_h-CD161+CD314+CD159a+CD159c-CD57+GranzymeB+Perforin-TIGIT-CD85j-/low) and cluster 15 (46.5% of total NK cells in HCC liver donor 1; CD56dimCD16+CD159c-CD158b, a_h-CD161+CD314-CD159a+CD159c-CD57+GranzymeB+Perforin-TIGIT-CD85j-). This evidence concerns the gene KIR2DL3 and hepatocellular carcinoma.