The clinical relevance of several markers included in this panel is further emphasized by a recent study in which the presence of NK cells with a specific expression profile (expressing higher levels of CD57, NKG2c, CD314 and CD335 and lower levels of TIGIT and NKG2a) could predict HCC recurrence risk and was related to the specific tumor location sampled (114). Here, TIGIT is linked to hepatocellular carcinoma.