Circadian clock disturbances impair the stability and function of Treg cells through PER1-related cytochrome c oxidase subunit 7C (COX7C) - dependent mitochondrial metabolic processes, exacerbating diseases such as autoimmune uveitis (90), indicating that PER1 is a key factor in maintaining the stability and function of regulatory T (Treg) cells. This evidence concerns the gene COX7C and autoimmune uveitis.