A study suggested that PER1 promotes ferroptosis and dysfunctional lipid metabolism in granulosa cells in polycystic ovary syndrome (PCOS) by inhibiting sterol regulatory element-binding factor 2 (SREBF2)/arachidonate 15-lipoxygenase (ALOX15) signaling pathway (84). Here, SREBF2 is linked to polycystic ovary syndrome.