Consistent with the previous verification (39), immunohistochemical staining of tumor tissues harvested from nude mice revealed that RPL41 treatment led to decreased expression levels of ATF4 (Figures 5A, B) and ARL5B (Figures 5C, D) in RB tissue, suggesting that RPL41 could inhibit the expression of these proteins. Here, ATF4 is linked to retinoblastoma.