CD4+ T cells participate in immune regulation after ischemic stroke through differentiation into Th1 and Th2 subsets; Th1 cells promote neuroinflammation by secreting IFN-γ mediated via IP-10, whereas Th2 cells exert anti-inflammatory effects by producing IL-10 and reducing infarct volume, although their precise roles remain controversial in current research (89). The gene discussed is CD4; the disease is ischemic stroke.