Clonal hematopoiesis of indeterminate potential (CHIP) serves as a critical precursor to leukemogenesis, characterized by recurrent mutations—most frequently in DNMT3A, TET2, and ASXL1—that emerge in otherwise healthy individuals and significantly elevate the risk of AML and other myeloid neoplasms (9, 10). The gene discussed is TET2; the disease is acute myeloid leukemia.