COL1A1 and Wilson disease: Additionally, in mWD-CH-WD mice, increased expression of fibrosis-associated genes Col1a1 (versus mWD-CH-CH) and Tgfb1 (versus mCH-CH-WD and mWD-CH-CH) was observed (Figure 3H), whereas picrosirius red staining was not different between groups (Figures 3I, J).