Notably, the emergence of increased expression of the inflammasome gene Nlrp3 and pro-fibrotic genes Col1a1 and Tgfb1 in young adult mice after just 4 weeks of post-weaning WD exposure (mWD-CH-WD) is surprising when considering adult WD fed models take up to 32 weeks to develop fibrosis (46). This evidence concerns the gene COL1A1 and Wilson disease.