HMOX1 and hydrops fetalis: As illustrated in Figure 1, the HF diet significantly downregulated the mRNA expression of antioxidant-related genes, including nuclear factor erythroid 2-related factor 2 (nrf2), superoxide dismutase 1 (sod1), catalase (cat), glutathione peroxidase (gpx), heme oxygenase 1 (ho-1), and glutathione reductase (gr), compared to the Control group (P < 0.05).