Inadequate angiogenesis is one of the causes of tissue ischemia, with T3 inducing myocardial angiogenesis through PDGF/Akt, αVβ3 integrin MAPK, FGF2, and TRβ mediation (Gerdes, 2015; Makino et al., 2009). This evidence concerns the gene AKT1 and ischemia.