KRAS and non-small cell lung carcinoma: Therefore, this study highlights the potential relevance of the EGFR allosteric site, which computational models suggest may intersects with the key regions of the TK receptor-ligand interface.28 It has also been stated that anaplastic lymphoma kinase (ALK), reactive oxygen species (ROS1), kinase-renin-angiotensin system (KRAS), protein kinase B (PKB), or (AKT) are other validated tissue biomarkers in NSCLC due to its downregulation of EGFR kinase in cell proliferation.29 Targeting the allosteric site stabilizes the protein complex, influencing the binding efficiency of the primary ligand.