As a precursor cytokine for bone marrow red blood cells, endogenous erythropoietin is secreted by the kidneys, regulates the generation of red blood cells, and is essential for red blood cell production.7,9 The effectiveness of rHuEPO in treating perioperative anemia in fracture patients has been confirmed by relevant studies.17,18. The gene discussed is EPO; the disease is anemia (phenotype).