Future studies investigating whether GPM6B interacts with Integrin β1 through lipid rafts, and whether the Integrin β1–β-catenin signaling pathway functionally intersects with regulatory networks involved in autophagy and apoptosis, will deepen researchers’ understanding of its role in glioma pathogenesis and provide novel theoretical foundations for potential therapeutic strategies. The gene discussed is GPM6B; the disease is glioma.