Since Perifosine functionally interrupted paracrine-mediated migration, one of the signaling pathways other than AKT that can be inhibited by Perifosine, e.g., ERK as shown in Fig. 4(e), may be involved in the process and should be studied to further understand intra-tumor paracrine cell signaling between heterotypic cell populations in OSCC. This evidence concerns the gene AKT1 and neoplasm.