It has been found in GBM that glucose transporter type 1 (GLUT1), HIF-1α, lactate dehydrogenase (LDH), and MCT4 were significantly expressed in the interior region of the tumor, whereas MCT1, C-MYC, and nuclear respiratory factor 1 (NRF1) were significantly expressed in the lateral region (57). This evidence concerns the gene NRF1 and glioblastoma.