Then there is the M2 macrophage state associated with anti-inflammatory effects, tissue repair and remodeling, promotion of angiogenesis, wound healing, suppression of T-cell responses, secretion of cytokines like IL-10 and transforming growth factor beta (TGF-β), and expression of arginase 1 (ARG1), VEGF, and CD206 among others, essentially activity to promote tumor progression (56, 58). The gene discussed is VEGFA; the disease is neoplasm.