Therefore, CAFs acquire features important to tumor progression, such as migratory capacity, ECM, chemokines, and growth factors, such as synthesis of transforming growth factor−β (TGFβ), platelet-derived growth factors (PDGFs), epidermal growth factors (EGFs), and fibroblast growth factors (FGFs) (8, 54). Here, TGFB1 is linked to neoplasm.