VEGFA and neoplasm: Normally, they are involved in the wound-healing process, but through proximity and crosstalk with tumor cells, they may take on either protumor activity, promoting cellular migration, pro-angiogenic cytokine synthesis, such as vascular endothelial growth factor A, and inflammation and plasticity of cancer stem cells (8); or a tumor-suppressive role, via the nuclear factor kappa-light-chain-enhancer of activated B-cell pathway (9).