The literature search identified a total of 3,535 records, including 1,034 duplicates, for a total of 16 CAF biomarkers in CRC, namely, CD163, CXCL12, matrix metalloproteinase 9 (MMP-9), MMP-2, periostin (POSTN), calcium-binding protein S100A4 (S100A4), tenascin C (TNC), vimentin (VIM), transgelin 2 (TAGLN2), platelet-derived growth factor subunit α/β (PDGFR-α/β), PDPN, α-SMA, alpha-fibroblast activation protein (αFAP), collagen type I alpha 1 chain (COL1A1), collagen type XI alpha 1 chain (COL11A1), and decorin (DCN). Here, CXCL12 is linked to colorectal carcinoma.