Regarding its pathogenesis, some studies suggest that DDLPS shares characteristic genomics similar to ALT/WDLPS, originating from an excessive ring chromosome or giant chromosome on the long arm of chromosome 12 (12q), containing a highly amplified 12q14–15 region, including the MDM2 gene located at 12q15 (10). The gene discussed is MDM2; the disease is dedifferentiated liposarcoma.