Li et al. [43] conducted a 113-patient cohort study revealing significant ZFAS1 upregulation in tumor tissues, showing robust associations with microvascular invasion (P = 0.028) and early postoperative recurrence (P = 0.041); Duan et al. [44] further validated these findings through TCGA database analysis (369 tumors vs 160 normal), where elevated ZFAS1 expression correlated with advanced clinical stage (P < 0.001) and lymph node metastasis (P = 0.001). The gene discussed is ZFAS1; the disease is neoplasm.