Recently, in an adriamycin-induced mouse nephropathy model, TRPC6-targeted Dex-loaded nanobubles (Dex@NBs), administered at half the dosage of free Dex, markedly alleviated proteinuria, glomerular and tubular damage, renal apoptosis, inflammation, and fibrosis (Wu et al., 2025), which were aligned with our findings, enhancing MP’s organization within the cells and reducing both mRNA expression and protein dispersion during PAN-induced podocyte damage featuring elevated TRPC6 expression. Here, TRPC6 is linked to Nephropathy.