TRPC6 and focal segmental glomerulosclerosis: It was also shown that TRPC6 gene variation in glomerular human glomerular diseases, including MCD, FSGS, and immune complex associated glomerulonephritis (Sun et al., 2021), and TRPC6 overexpression in podocytes correlate with decreased calpastatin expression, autophagy blockade, and podocyte injury in DN (Salemkour et al., 2023).