CD4 and neoplasm: - T cells within RCRC exhibit a highly differentiated and recently activated state. Immunofluorescence staining for CD4 and CD8 markers identified that RCRC is enriched for CD8+ T cells- A subpopulation of T cells in RCRC are in an exhaustion state: the increased presence of these cells frequently signifies a positive reaction of the immune system towards the tumor and may result in a more favorable prognosis when utilized together with immune checkpoint therapy