- Tumor sidedness has a minimal effect on the ICL/ICRs expression pattern and is not an effective predictor for immune checkpoint blockade-based immunotherapies- CD4+ T cells in LCRC have significantly higher levels of oxidative phosphorylation and the TCA cycle than those in RCRC, suggesting a higher T cell function in LCRC (similar results were also observed in CD8+ T cells)- Tumor sidedness has minimal effect on cell-to-cell communication. The gene discussed is CD8A; the disease is neoplasm.