ATF3 and neoplasm: For instance, sc-seq has uncovered malignant cell subclusters enriched in genes associated with histone deacetylase (HDAC) inhibitor response (ATF3, CAV1), inflammation (LXN, PGM1), and hypoxia-linked tumor metastasis (WSB1) (Xiao et al., 2024), highlighting their importance in tumor progression.