- Tumor cell subclusters enriched with gene response to HDAC inhibitors (ATF3 and CAV1), inflammatory genes (LXN and PGM1) and tumor metastasis-related hypoxia (WSB1) were identified- Tumor cells expressed TMSB4X at high level (a validated therapeutic target)- Subregions of the tumor included enhanced focal adhesion dynamics, metabolic and hypoxia-response modules, suggesting their involvement in tumor progression. Here, TMSB4X is linked to neoplasm.