- Proliferation, stemness and immune secretory meta-programs show inverted expression patterns in malignant epithelium from LCRC and RCRC tumors (validated in several cohorts)- The IS meta-program has increased expression of MHCII molecules (CD74, HLA-DRB1, and HLA-DPA1) and secretory protein molecules (REG4, AGR2, and AGR3), with AGR2 and REG4 specifically expressed in RCRC.- IShigh malignant epithelium is in close proximity to the hypoxic tumor core and is collocated with SPP1+ TAMs and CD161+ CD8+ T cells. Here, AGR3 is linked to neoplasm.