In a study of Cao et al., LCRC lower malignancy score is linked to lysophosphatidylcholine acyltransferase 2-positive (LPCAT2+) tumor cells (Cao et al., 2024), with LPCAT2+ tumor cells significantly expanding in the inflammatory phase of a colitis-associated colon cancer mouse model. Here, LPCAT2 is linked to colonic neoplasm.