TIMP1 and colorectal carcinoma: - Bulk TCGA analysis identified MTRGs DEGs between normal and tumorous tissues to build a four-gene prognostic model- Only TIMP1 gene expression level significantly increased during epithelial cell pseudo-time analysis (HPA database confirmed high TIMP1 expression in CRC)- High-risk patients demonstrated lower IC50 levels in response to elesclomol, shikonin, and bryostatin-1 (agents predicted to target TIMP1)