HAVCR2 and neoplasm: Furthermore, the pervasive inhibitory communication networks among myeloid, mast, B, and tumor cells via axes such as immune cell inhibition by tumor cells via CD24-SIGLEC10 and LGALS9-HAVCR2 interactions appear to be a fundamental characteristic of the CRC microenvironment, with minimal influence from sidedness (Barkal et al., 2019; Hill et al., 2025).