SPP1 and neoplasm: - C1QC+ TAMs express genes related to phagocytosis and antigen presentation- SPP1+ TAMs are enriched for regulators of angiogenesis and metastatic liver cancer pathways and are increased in tumor vs. normal mucosa- Anti-CSF1R treatment reduces overall TAM numbers in Renca tumor-bearing mice but reveals a resistant population with decreased F4/80 expression. Resistant TAMs preferentially express angiogenesis (VEGFA) and immunosuppression (CD274, ARG1) genes and are associated with tumor vascularization