The latter activates genes linked to proliferation and stem-like properties (for example, UBE2C, MYBL2 and ALDH1A1), and these proliferative tumor cells are often found in highly glycolytic niches within the tumor and are supported by specific immune cells, including PLTP+ macrophages, activated Tregs, and LAYN+ CD8+ cells. The gene discussed is UBE2C; the disease is neoplasm.