Not only is the hepatic synthesis of clotting factors (Factors II, V, VII, IX, X, and XI) markedly reduced, but thrombocytopenia and platelet dysfunction are also common due to hypersplenism, decreased thrombopoietin production, and impaired platelet aggregation, as well as dysregulated fibrinolysis [3]. The gene discussed is THPO; the disease is Thrombocytopenia.