In vivo, TPI catalyzes thereversible isomerization of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.A rare genetic disease called TPI deficiency disrupts this reactionand causes hemolytic anemia and progressive neuromuscular dysfunctionleading to premature death., Further, due to itskey role in glycolysis, TPI is becoming increasingly appreciated asa cancer target., Here, TPI1 is linked to cancer.