XK and ATP11C preserve membrane integrity: XK loss causes McLeod syndrome with acanthocytosis and reduced deformability that may impair merozoite entry (Roulis et al., 2018), while ATP11C-mediated phosphatidylserine flipping prevents premature PS exposure and macrophage clearance (Arashiki et al., 2016; Nagata et al., 2016; Shin and Takatsu, 2019). This evidence concerns the gene XK and McLeod neuroacanthocytosis syndrome.