Hence, dysregulation of FOXO3a and FOXO1 has been associated with poor pregnancy outcomes, such as preeclampsia and gestational diabetes mellitus (Zhang et al., 2020b; Chen et al., 2021; Zhang et al., 2022a; Chen et al., 2018; Ding et al., 2023; Akkaya Firat et al., 2025). The gene discussed is FOXO3; the disease is preeclampsia.