Further exploratory analysis revealed that GDM was associated with a decreased risk in the presence of the TT genotype of PPARGC1A rs8192678 C > T (OR: 0.417; 95% CI: 0.225–0.774) and the CC genotype of GCK rs2971672 A > C (OR: 0.470; 95% CI: 0.262–0.846) compared to wild types. The gene discussed is GCK; the disease is gestational diabetes.