In an exploratory analysis using logistical regression, the odds ratio (OR) for GDM was 0.417 (95% CI: 0.225–0.774) among women with the TT genotype of PPARGC1A rs8192678 and 0.470 (95% CI: 0.262–0.846) among those with the CC genotype of GCK rs2971672 compared to the wild type. The gene discussed is PPARGC1A; the disease is gestational diabetes.