MAPT and Alzheimer disease: As shown in Table 11, Figures 13A–E, the AD model group exhibited significant elevations in the ratios of p-NF-κB p65/NF-κB p65, MMP-9/β-actin, and p-Tau/Tau, together with a marked reduction in p-GSK-3β/GSK-3β (vs. Normal group, P < 0.001, P < 0.01, P < 0.001, and P < 0.01, respectively), indicative of aggravated neuroinflammation and aberrant Tau hyper-phosphorylation.