KEGG enrichment pathways included calcium signaling pathway, TNF, PI3K-Akt, HIF-1, neuroactive ligand-receptor interaction, cAMP, MAPK, apoptosis, and NF-κB signaling pathways, among which the calcium signaling pathway is closely related to AD mechanisms and may be an essential signaling pathway through which MFXD improves cognitive dysfunction. Here, TNF is linked to Alzheimer disease.