MAPT and Alzheimer disease: The pathogenesis of AD remains unsettled; its major pathological hallmarks include cerebral neuroinflammation, mitochondrial dysfunction, neurofibrillary tangles arising from hyperphosphorylated Tau (Protein Tau), and senile plaques formed by amyloid-β (Aβ) deposition (Meng et al., 2019; Pascoal et al., 2021; Ashleigh et al., 2023).