The study by Wang et al. (54) showed that serum occludin [OR = 2.721, 95%CI (1.100, 6.730)] and zonula occludens-1 (ZO - 1) [OR = 2.824, 95%CI (1.162, 6.862)] were influencing factors for the occurrence of cognitive impairment in older adults patients with acute cerebral infarction (p < 0.05). The gene discussed is OCLN; the disease is Cognitive impairment.