Female gender, hypertension, systolic blood pressure, diabetes mellitus, hyperlipidemia, carotid plaque, location of infarct (frontal lobe, temporal lobe), multiple cerebral infarctions, brain atrophy, Hcy, hyperhomocysteinemia, Hs-CRP, and NIHSS score are the influencing factors for cognitive impairment in Chinese older adults stroke patients. The gene discussed is CRP; the disease is hyperlipidemia.