Female gender, hypertension, systolic blood pressure, diabetes mellitus, hyperlipidemia, carotid plaque, location of infarct (frontal lobe and temporal lobe), multiple cerebral infarctions, brain atrophy, homocysteine (Hcy), hyperhomocysteinemia, high-sensitivity C-reactive protein (Hs-CRP), and National Institutes of Health Stroke Scale (NIHSS) score are the influencing factors for cognitive impairment in older adults stroke patients in China. The gene discussed is CRP; the disease is Brain atrophy.