This epithelial injury triggers the release of alarmins IL-33 and TSLP (110), activates innate lymphoid cell types 2 (ILC2) and T cells, and promotes IL-5/IL-13-driven eosinophilic and interleukin-17A-mediated neutrophilic inflammation—resulting in mixed airway inflammation (111, 112). Here, IL33 is linked to inflammatory response.