HSPA1A/HSPA1B, as pivotal HSP70 family members, not only preserve protein homeostasis under stress conditions through chaperone function but also suppress tumor cell apoptosis via PI3K/Akt pathway activation, concordant with scPAS + cell survival advantages within tumor hypoxic and nutrient-depleted microenvironments. The gene discussed is HSPA1B; the disease is neoplasm.