Coordinated expression of these genes suggests the M17 module may constitute the core functional unit positioning scPAS + cells as “tumor seed cells.” The M20 gene module primarily comprises TOP2A, UBE2C, and STMN1, principally regulating cell proliferation and promoting hepatocellular carcinoma growth (Figure 2D). The gene discussed is UBE2C; the disease is hepatocellular carcinoma.