Common ADRs include gastrointestinal bleeding, hypoglycemia, nephrotoxicity, and central nervous system depression, while high-risk interactions frequently involve drugs such as warfarin, non-steroidal anti-inflammatory drugs (NSAIDs), angiotensin-converting enzyme (ACE) inhibitors, and selective serotonin reuptake inhibitors (SSRIs). Here, ACE is linked to Hypoglycemia.