Salivary biomarkers such as proteins (IL-8, IL-6, MMP-9), genetic and epigenetic markers (p53 mutations, hypermethylation of p16 and DAPK, miRNA signatures such as miR-31 and miR-200a), and metabolic profiles (polyamines, lactic acid, phenylalanine) have shown high specificity and sensitivity in distinguishing healthy subjects from OSCC patients in oral cancer detection and screening [7] (Figure 2). This evidence concerns the gene TP53 and lip and oral cavity carcinoma.