Elevated concentrations of IL-6 (pg/mL), homocysteine (μmol/L), ADMA (ng/mL), uric acid (mg/dL), and NT-proBNP (pg/mL) reflect systemic inflammation, endothelial dysfunction, metabolic abnormalities, and cardiac strain in patients with chronic kidney disease. The gene discussed is NPPB; the disease is chronic kidney disease.