ABCD‐associated insulin resistance can promote insulin‐like growth factor (IGF), leptin, and adiponectin signaling, which may increase PCa risk [20], and TNFα, IL‐1β, and IFNδ from T‐cells and macrophages act through cell surface receptors to stimulate intracellular pathways that promote insulin resistance [19]. The gene discussed is LEP; the disease is Insulin resistance.