Also, in mouse models, obesity‐associated IGF‐1 is believed to promote PCa oncogenesis via PI3/AKT, Forkhead Box 0 3A (FOXO3A), and B‐cell Lymphoma 2‐like protein 11 (BIM) signaling [21], and both in vitro and in vivo studies of IGF‐1 receptor activation in PCa reveal angiogenesis and activation of cellular survival pathways via a5b1 integrin expression [22]. Here, PI3 is linked to posterior cortical atrophy.