For the most connected biomarkers (IL‐1β, MCP‐1, and CXCL1), GSEA found GO categories with molecular functions such as glycosaminoglycan and integrin binding, immune receptor activity, and extracellular matrix functional constituents (as a part of ECM remodeling), which may all relate to inflammation, the immune response to bacteria, and PCa progression within the TME. Here, CXCL1 is linked to posterior cortical atrophy.