CD274 and neoplasm: Moreover, studies have shown that tumor-derived INHBA can dampen the response to immune checkpoint blockade by suppressing interferon-γ (IFN-γ) pathway, reducing programmed death-ligand 1 (PD-L1), and impairing T-cell chemokines secretion like C-X-C motif chemokine ligand 9/10 (CXCL9/10).