INHBA and colorectal carcinoma: To elucidate how INHBA promotes the malignant progression of CRC, we used 24 immune cell signature genes defined by Bindea et al. (Immunity, 2013).43 By applying ssGSEA to the TCGA-COAD dataset, we quantified immune-subpopulation infiltration levels and performed unsupervised hierarchical clustering to classify samples into high- and low-immune infiltration cohorts.