This receptor is a key node in cellular metabolic pathways, critically modulates immune homeostasis, and orchestrates inflammatory responses.31 Studies have shown that tumor-derived succinate can activate the SUCNR1 on macrophages, polarizing them into M2-type TAMs and thereby promoting oncogenic signaling.32 Solute carrier family 25 member 10 (SLC25A10), alternatively termed the mitochondrial dicarboxylate ion carrier (DIC), is a mitochondrial transporter which primarily facilitates mitochondrial metabolite exchange. The gene discussed is SUCNR1; the disease is neoplasm.