TRIM21 and neoplasm: Moreover, a study leveraging the Clinical Proteomic Tumor Analysis Consortium (CPTAC) database and a tissue microarray containing 427 CRC tissues together with their matched adjacent normal mucosa samples demonstrated that TRIM21 is significantly downregulated in tumors; low TRIM21 abundance predicted shorter OS and worse disease-specific survival (DSS).47 On the basis of these findings, we postulated that INHBA protects SLC25A10 from ubiquitin–proteasome–mediated degradation.