TP53 and neoplasm: Analysis of upstream regulators of these DEGS (Fig. 4D showing upstream regulators of DEGs of cluster 4, unraveled activation of several tumor suppressors, such as hepatocyte nuclear factor 4A, TP53, and transforming growth factor β1 (TGFB1), and inhibition of the hepatocarcinogen diethylnitrosamine in AEG-1ΔMAC hepatocytes.