Our recent work revealed that a hepatocyte-specific AEG-1 transgenic mouse (Alb/AEG-1) develops spontaneous MASH, and a hepatocyte-specific conditional AEG-1 knockout mouse (AEG-1ΔHEP) is protected from high-fat diet (HFD)–induced MASH (8). This evidence concerns the gene MTDH and metabolic dysfunction-associated steatohepatitis.