HPD and neoplasm: Accordingly, tumor-promoting genes, such as epidermal growth factor receptor (Egfr) and lipocalin 2 (Lcn2), were significantly overexpressed, and tumor suppressor genes, such as glycine N-methyltransferase (Gnmt) and 4-hydroxyphenylpyruvate dioxygenase (Hpd), were significantly downregulated in the hepatocytes of AEG-1fl/fl livers versus AEG-1ΔMAC livers (Fig. 7B and Table S4) (26, 27, 28, 29).