Compared to the no incident AF group, the incident AF cohort had more individuals of male sex (93.0% vs 78.8%) and White race (78.9% vs 61.5%) but fewer with a genetic variant of ATTR (25.4% vs 49.0%), NYHA class I functional status (8.5% vs 21.2%), and history of hypertension (42.3% vs 58.7%). The gene discussed is TTR; the disease is atrial fibrillation.