Notwithstanding, data on NSE and functional outcomes gave conflicting results, with some studies reporting statistical significance between blood levels and recovery at discharge or in the early days after stroke, assessed by the modified Rankin Scale (mRS) [51, 53] a commonly used scale to measure the degree of disability or dependence in daily activities after a stroke event, whereas others founding no association [54–56]. The gene discussed is ENO2; the disease is Stroke.