In stroke, several promising blood biomarkers, such as brain derived proteins like brain-derived tau (BD-tau), glial fibrillar acid protein (GFAP) [13], neurofilament light chain (NfL) and Neuron-specific enolase (NSE), as well as neurotrophic factors like brain-derived neurotrophic factor (BDNF) or inflammatory markers, have been associated with stroke recovery [14–16]. The gene discussed is ENO2; the disease is Stroke.