GSEA analysis showed that the LUAD sample with high IGSF10 expression exhibited significant negative enrichment in the cell cycle (NES = −1.547, FDR = 0.034) and oxidative phosphorylation (NES = −2.069, FDR = 3.90 × 10−5), and negative enrichment in the arachidonic acid metabolism (Figure 5C), indicating that IGSF10 exerts a potent anti‐cancer effect by simultaneously inhibiting tumour cell proliferation and mitochondrial energy metabolism. This evidence concerns the gene IGSF10 and neoplasm.