Based on gene ontology (GO) enrichment analysis of upregulated and downregulated genes, our results showed that IGSF10‐related genes were mainly enriched in the processes of inhibiting cell migration, adhesion, and epithelial‐mesenchymal transition (EMT), as well as enhancing epithelial differentiation, which strongly supports its antitumor role in lung adenocarcinoma (Figure 5B). This evidence concerns the gene IGSF10 and lung adenocarcinoma.