Meanwhile, in LUAD, there was a significant negative correlation between IGSF10 and key immunosuppressive factors (CD47, CD276) and tumour microenvironment regulators (IGSF3, IGSF8) among IGSF family members, indicating that the downregulation of IGSF10 is part of the IGSF family network dysregulation, which collectively affects the tumour microenvironment and promotes tumour progression and immune escape. The gene discussed is IGSF3; the disease is neoplasm.