IGSF10 and neoplasm: We observed significant downregulation of IGSF10 in 21 tumours, such as UCEC (Tumour: 0.75 ± 0.79, Normal: 1.94 ± 1.16, p = 1.2e‐7), BRCA (Tumour: 1.09 ± 0.84, Normal: 3.73 ± 0.79, p = 1.9e‐62), LUAD (Tumour: 1.27 ± 0.95, Normal: 3.99 ± 0.68, p = 3.6e‐55), STAD (Tumour: 0.62 ± 0.65, Normal: 1.17 ± 0.87, p = 4.7e‐5), HNSC (Tumour: 0.71 ± 0.83, Normal: 1.65 ± 1.01, p = 2.9e‐11), LUSC (Tumour: 1.70 ± 1.08, Normal: 3.99 ± 0.68, p = 1.5e‐49), etc. (Figure 1A).