IGSF10 and cartilage-hair hypoplasia: For example, IGSF10 mutations can result in delayed puberty via dysregulating gonadotropin‐releasing hormone (GnRH) neuronal migration and IGSF10 deficiency‐triggered transient GnRH deficiency may lead to a reversible congenital hypogonadotropic hypogonadism (CHH) [9, 10, 11].