Interestingly, while we were unable to show directly that pancreatic cDC1s are impacted by intestinal cDC1s due to difficulty in pancreatic cDC1 tracing methods, we found an increase in IL‐12p40+ liver‐derived cDC1s upon intestinal viral infections, suggesting potential communication between inflammatory cDC1s in the LN. Here, MPPE1 is linked to viral infectious disease.