Hospitalization after outpatient investigations revealed significant hypoalbuminemia (serum albumin 19.3 g/L), proteinuria (2+), hematuria (3+), and 24 h urinary protein excretion of 1.18 g, leading to a provisional diagnosis of chronic glomerulonephritis with hypoalbuminemia. The gene discussed is ALB; the disease is Hypoalbuminemia.