For instance, while PEComas can share some histological features and may rarely harbor TFE3 rearrangements (often with different fusion partners), and RCC variants can exhibit clear cells and vascularity, the presence of the definitive ASPSCR1-TFE3 fusion is pathognomonic for ASPS. This evidence concerns the gene ASPSCR1 and neoplasm with perivascular epithelioid cell differentiation.