After simultaneous adjustment in multivariate Cox model, age (HR = 1.05, 95% CI 1.02–1.08, P = 0.002) and low WBC (HR = 0.38, 95% CI 0.17–0.82, P = 0.014) were still independently associated with HCC occurrence, whereas C4 and CIV did not reach statistical significance (C4: HR = 1.09, 95% CI 0.52–2.31, P = 0.82; CIV: HR = 0.52, 95% CI 0.16–1.73, P = 0.29; Table 5). Here, C4A is linked to hepatocellular carcinoma.