Accordingly, regulation of apoptotic signaling is important in BPH, where B-cell lymphoma 2 (Bcl-2) promotes cell survival and Bcl-2–associated X protein (Bax) promotes apoptosis, providing opposing control over epithelial and stromal cell turnover (Pereira Soares et al., 2014). This evidence concerns the gene BAX and benign prostatic hyperplasia.