PRMT1 and endothelial dysfunction: PRMT inhibition ameliorates symptoms associated with spinal muscular atrophy (SMA) by targeting neuroinflammation, suggesting its potential as a standalone or adjunctive treatment.20 The imbalance between PRMT1 and DDAH (dimethylarginine dimethylaminohydrolase) is associated with hyperglycemia-induced endothelial dysfunction.