Modulation of PD-L1 expression through overexpression or knockdown (Figures S3C and S3D) significantly altered the cytotoxic effects of osimertinib: PD-L1 overexpression decreased tumor cell sensitivity to osimertinib, whereas PD-L1 knockdown markedly enhanced its cytotoxicity against tumor cells (Figures S4D–4F). The gene discussed is CD274; the disease is neoplasm.