,23,24 Predominant microorganisms enriched in CRC include Fusobacterium nucleatum, polyketide synthase (pks)+Escherichia coli, and B. fragilis.25,26,27 These intratumoral microbiota promote CRC progression by modulating intestinal epithelial cells, neoplastic cells, and tumor microenvironment. The gene discussed is ARAF; the disease is colorectal carcinoma.